Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites

INTRODUCTION: Metoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases. Metabolomics, the study of end-stage metabolites of upstream biologic processes, yield insight into mechanisms of drug effectiveness and safety. Our...

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Detalhes bibliográficos
Publicado no:Hum Genomics
Main Authors: Brocker, Chad N., Velenosi, Thomas, Flaten, Hania K., McWilliams, Glenn, McDaniel, Kyle, Shelton, Shelby K., Saben, Jessica, Krausz, Kristopher W., Gonzalez, Frank J., Monte, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066769/
https://ncbi.nlm.nih.gov/pubmed/32160915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-020-00260-w
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