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The Effect of CYP2D6 Drug-Drug Interactions on Hydrocodone Effectiveness
OBJECTIVES: The hepatic cytochrome 2D6 (CYP2D6) is a saturable enzyme responsible for metabolism of approximately 25% of known pharmaceuticals. CYP interactions can alter the efficacy of prescribed medications. Hydrocodone is largely dependent on CYP2D6 metabolism for analgesia, ondansetron is inact...
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Main Authors: | , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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2014
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150819/ https://ncbi.nlm.nih.gov/pubmed/25156930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acem.12431 |
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