An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family

A mutant of the high fidelity family-B DNA polymerase from the archaeon Thermococcus gorgonarius (Tgo-Pol), able to replicate past DNA lesions, is described. Gain of function requires replacement of the three amino acid loop region in the fingers domain of Tgo-Pol with a longer version, found natura...

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Autori principali: Jozwiakowski, Stanislaw K., Keith, Brian J., Gilroy, Louise, Doherty, Aidan J., Connolly, Bernard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150786/
https://ncbi.nlm.nih.gov/pubmed/25063297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku683
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