Novel inhibition of archaeal family-D DNA polymerase by uracil

Archaeal family-D DNA polymerase is inhibited by the presence of uracil in DNA template strands. When the enzyme encounters uracil, following three parameters change: DNA binding increases roughly 2-fold, the rate of polymerization slows by a factor of ∼5 and 3′–5′ proof-reading exonuclease activity...

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Bibliografiske detaljer
Main Authors: Richardson, Tomas T., Gilroy, Louise, Ishino, Yoshizumi, Connolly, Bernard A., Henneke, Ghislaine
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627576/
https://ncbi.nlm.nih.gov/pubmed/23408858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt083
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