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Novel inhibition of archaeal family-D DNA polymerase by uracil
Archaeal family-D DNA polymerase is inhibited by the presence of uracil in DNA template strands. When the enzyme encounters uracil, following three parameters change: DNA binding increases roughly 2-fold, the rate of polymerization slows by a factor of ∼5 and 3′–5′ proof-reading exonuclease activity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627576/ https://ncbi.nlm.nih.gov/pubmed/23408858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt083 |
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