Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya

Family B DNA polymerases from archaea such as Pyrococcus furiosus, which live at temperatures ∼100°C, specifically recognize uracil in DNA templates and stall replication in response to this base. Here it is demonstrated that interaction with uracil is not restricted to hyperthermophilic archaea and...

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Detalhes bibliográficos
Main Authors: Wardle, Josephine, Burgers, Peter M. J., Cann, Isaac K. O., Darley, Kate, Heslop, Pauline, Johansson, Erik, Lin, Li-Jung, McGlynn, Peter, Sanvoisin, Jonathan, Stith, Carrie M., Connolly, Bernard A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241895/
https://ncbi.nlm.nih.gov/pubmed/18032433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1023
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