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Regulation of Immunoglobulin Class-Switch Recombination: Choreography of Noncoding Transcription, Targeted DNA Deamination, and Long-Range DNA Repair

Upon encountering antigens, mature IgM-positive B lymphocytes undergo class-switch recombination (CSR) wherein exons encoding the default Cμ constant coding gene segment of the immunoglobulin (Ig) heavy-chain (Igh) locus are excised and replaced with a new constant gene segment (referred to as “C(h)...

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Detalhes bibliográficos
Main Authors: Matthews, Allysia J., Zheng, Simin, DiMenna, Lauren J., Chaudhuri, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150736/
https://ncbi.nlm.nih.gov/pubmed/24507154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-800267-4.00001-8
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