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Rational Design of Substrate-Based Multivalent Inhibitors of the Histone Acetyltransferase
Tip60 (the 60-kDa HIV-1 Tat-interactive protein) is a key member of the MYST family of histone acetyltransferases (HATs) and plays critical roles in apoptosis and DNA repair. Potent and selective inhibitors for Tip60 are valuable tools for studying the functions of the enzyme. In this work, we desig...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150253/ https://ncbi.nlm.nih.gov/pubmed/24446345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300478 |
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