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Rational design and validation of a Tip60 histone acetyltransferase inhibitor
Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4064327/ https://ncbi.nlm.nih.gov/pubmed/24947938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05372 |
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