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SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60
The histone acetyltransferase TIP60, a frequent target of monoallelic loss in human carcinomas, can acetylate many substrates, including histones and p53, and thus promote apoptosis following UV radiation. Here we showed that TIP60 is autoacetylated in response to UV damage, which is critically impo...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857024/ https://ncbi.nlm.nih.gov/pubmed/20100829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087585 |
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