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Rational design and validation of a Tip60 histone acetyltransferase inhibitor

Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Gao, Chunxia, Bourke, Emer, Scobie, Martin, Famme, Melina Arcos, Koolmeister, Tobias, Helleday, Thomas, Eriksson, Leif A., Lowndes, Noel F., Brown, James A. L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064327/
https://ncbi.nlm.nih.gov/pubmed/24947938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05372
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