Labeling Lysine Acetyltransferase Substrates with Engineered Enzymes and Functionalized Cofactor Surrogates

Elucidating biological and pathological functions of protein lysine acetyltransferases (KATs) greatly depends on the knowledge of the dynamic and spatial localization of their enzymatic targets in the cellular proteome. Here we report the design and application of chemical probes for facile labeling...

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Bibliografiske detaljer
Main Authors: Yang, Chao, Mi, Jiaqi, Feng, You, Ngo, Liza, Gao, Tielong, Yan, Leilei, Zheng, Yujun George
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703473/
https://ncbi.nlm.nih.gov/pubmed/23659802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja311636b
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