Deletion of the angiotensin II type 1 receptor–associated protein enhances renal sodium reabsorption and exacerbates angiotensin II–mediated hypertension

Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation of tissue AT1R signaling. However, the functional significance of ATRAP in renal sodium handling and blood pressure regulation under pathological stimuli i...

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Bibliografische gegevens
Hoofdauteurs: Ohsawa, Masato, Tamura, Kouichi, Wakui, Hiromichi, Maeda, Akinobu, Dejima, Toru, Kanaoka, Tomohiko, Azushima, Kengo, Uneda, Kazushi, Tsurumi-Ikeya, Yuko, Kobayashi, Ryu, Matsuda, Miyuki, Uchida, Shinichi, Toya, Yoshiyuki, Kobori, Hiroyuki, Nishiyama, Akira, Yamashita, Akio, Ishikawa, Yoshihiro, Umemura, Satoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
Onderwerpen:
Basic Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149871/
https://ncbi.nlm.nih.gov/pubmed/24694992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2014.95
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