Deletion of the angiotensin II type 1 receptor–associated protein enhances renal sodium reabsorption and exacerbates angiotensin II–mediated hypertension

Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation of tissue AT1R signaling. However, the functional significance of ATRAP in renal sodium handling and blood pressure regulation under pathological stimuli i...

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Detalhes bibliográficos
Main Authors: Ohsawa, Masato, Tamura, Kouichi, Wakui, Hiromichi, Maeda, Akinobu, Dejima, Toru, Kanaoka, Tomohiko, Azushima, Kengo, Uneda, Kazushi, Tsurumi-Ikeya, Yuko, Kobayashi, Ryu, Matsuda, Miyuki, Uchida, Shinichi, Toya, Yoshiyuki, Kobori, Hiroyuki, Nishiyama, Akira, Yamashita, Akio, Ishikawa, Yoshihiro, Umemura, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149871/
https://ncbi.nlm.nih.gov/pubmed/24694992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2014.95
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