Circulating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis

Clusters of circulating tumor cells (CTC-clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammary tumors, we demonstrate that CTC-clusters arise from oligoclonal tumor cell groupings and not from intra...

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Detalhes bibliográficos
Main Authors: Aceto, Nicola, Bardia, Aditya, Miyamoto, David T., Donaldson, Maria C., Wittner, Ben S., Spencer, Joel A., Yu, Min, Pely, Adam, Engstrom, Amanda, Zhu, Huili, Brannigan, Brian W., Kapur, Ravi, Stott, Shannon L., Shioda, Toshi, Ramaswamy, Sridhar, Ting, David T., Lin, Charles P., Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149753/
https://ncbi.nlm.nih.gov/pubmed/25171411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.013
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