Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing

BACKGROUND: Human pluripotent stem cells (PSCs) play an important role in disease modeling and drug testing. However, the current methods are time consuming and lack an isogenic control. OBJECTIVES: To establish an efficient technology to generate human PSCs-based disease models with isogenic contro...

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Detalhes bibliográficos
Main Authors: Wang, Yongming, Liang, Ping, Lan, Feng, Wu, Haodi, Lisowski, Leszek, Gu, Mingxia, Hu, Shijun, Kay, Mark A., Urnov, Fyodor D., Shinnawi, Rami, Gold, Joseph D., Gepstein, Lior, Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149735/
https://ncbi.nlm.nih.gov/pubmed/25082577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2014.04.057
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