Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C

BACKGROUND AND AIMS: The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma. The aim of this study was to estimate the effect size of homozygosity for the PNPLA3 I148M variant (148M/M) on the fibrosis progressio...

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Main Authors: De Nicola, Stella, Dongiovanni, Paola, Aghemo, Alessio, Cheroni, Cristina, D'Ambrosio, Roberta, Pedrazzini, Michele, Marabita, Francesco, Donnici, Lorena, Maggioni, Marco, Fargion, Silvia, Colombo, Massimo, De Francesco, Raffaele, Valenti, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149487/
https://ncbi.nlm.nih.gov/pubmed/25171251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106022
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