Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs). Mono-allelic mutations in PALB2 increase the risk of breast, pancreatic, and other cancers, and biallelic mutations cause Fanconi anemia (FA). Like Brca1 and Brca2, systemic knock-out of Palb2 in mic...

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Detalhes bibliográficos
Main Authors: Simhadri, Srilatha, Peterson, Shaun, Patel, Dharm S., Huo, Yanying, Cai, Hong, Bowman-Colin, Christian, Miller, Shoreh, Ludwig, Thomas, Ganesan, Shridar, Bhaumik, Mantu, Bunting, Samuel F., Jasin, Maria, Xia, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148885/
https://ncbi.nlm.nih.gov/pubmed/25016020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566141
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