Biased Signaling Favoring G(i) over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

Apelin plays a prominent role in body fluid and cardiovascular homeostasis. We previously showed that the C-terminal Phe of apelin 17 (K17F) is crucial for triggering apelin receptor internalization and decreasing blood pressure (BP) but is not required for apelin binding or G(i) protein coupling. B...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ceraudo, Emilie, Galanth, Cécile, Carpentier, Eric, Banegas-Font, Inmaculada, Schonegge, Anne-Marie, Alvear-Perez, Rodrigo, Iturrioz, Xavier, Bouvier, Michel, Llorens-Cortes, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148883/
https://ncbi.nlm.nih.gov/pubmed/25012663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541698
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados