Biased Signaling Favoring G(i) over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

Apelin plays a prominent role in body fluid and cardiovascular homeostasis. We previously showed that the C-terminal Phe of apelin 17 (K17F) is crucial for triggering apelin receptor internalization and decreasing blood pressure (BP) but is not required for apelin binding or G(i) protein coupling. B...

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Main Authors: Ceraudo, Emilie, Galanth, Cécile, Carpentier, Eric, Banegas-Font, Inmaculada, Schonegge, Anne-Marie, Alvear-Perez, Rodrigo, Iturrioz, Xavier, Bouvier, Michel, Llorens-Cortes, Catherine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148883/
https://ncbi.nlm.nih.gov/pubmed/25012663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541698
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