By Interacting with the C-terminal Phe of Apelin, Phe(255) and Trp(259) in Helix VI of the Apelin Receptor Are Critical for Internalization

Apelin is the endogenous ligand of the orphan seven-transmembrane domain (TM) G protein-coupled receptor APJ. Apelin is involved in the regulation of body fluid homeostasis and cardiovascular functions. We previously showed the importance of the C-terminal Phe of apelin 17 (K17F) in the hypotensive...

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Bibliographic Details
Main Authors: Iturrioz, Xavier, Gerbier, Romain, Leroux, Vincent, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952265/
https://ncbi.nlm.nih.gov/pubmed/20675385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127167
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