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By Interacting with the C-terminal Phe of Apelin, Phe(255) and Trp(259) in Helix VI of the Apelin Receptor Are Critical for Internalization
Apelin is the endogenous ligand of the orphan seven-transmembrane domain (TM) G protein-coupled receptor APJ. Apelin is involved in the regulation of body fluid homeostasis and cardiovascular functions. We previously showed the importance of the C-terminal Phe of apelin 17 (K17F) in the hypotensive...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952265/ https://ncbi.nlm.nih.gov/pubmed/20675385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127167 |
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