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Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

Elevated levels of amyloid-β peptide (Aβ) in the human brain are linked to the pathogenesis of Alzheimer disease. Recent in vitro studies have demonstrated that extracellular Aβ can bind to exosomes, which are cell-secreted nanovesicles with lipid membranes that are known to transport their cargos i...

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Hlavní autoři: Yuyama, Kohei, Sun, Hui, Sakai, Shota, Mitsutake, Susumu, Okada, Megumi, Tahara, Hidetoshi, Furukawa, Jun-ichi, Fujitani, Naoki, Shinohara, Yasuro, Igarashi, Yasuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148874/
https://ncbi.nlm.nih.gov/pubmed/25037226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577213
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