The Peculiar Role of the A2V Mutation in Amyloid-β (Aβ) 1–42 Molecular Assembly

We recently reported a novel Aβ precursor protein mutation (A673V), corresponding to position 2 of Aβ1–42 peptides (Aβ1–42(A2V)), that caused an early onset AD-type dementia in a homozygous individual. The heterozygous relatives were not affected as an indication of autosomal recessive inheritance o...

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Autors principals: Messa, Massimo, Colombo, Laura, del Favero, Elena, Cantù, Laura, Stoilova, Tatiana, Cagnotto, Alfredo, Rossi, Alessandro, Morbin, Michela, Di Fede, Giuseppe, Tagliavini, Fabrizio, Salmona, Mario
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148846/
https://ncbi.nlm.nih.gov/pubmed/25037228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576256
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