MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s...

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Главные авторы: Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148706/
https://ncbi.nlm.nih.gov/pubmed/25088770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.016
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