MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s...

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Main Authors: Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148706/
https://ncbi.nlm.nih.gov/pubmed/25088770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.016
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