Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor α–Induced Inflammatory Arthritis

OBJECTIVE: Peptidylarginine deiminase 4 (PAD4) is a citrullinating enzyme that has multiple associations with inflammation. In rheumatoid arthritis, PAD4 and protein citrullination are increased in inflamed joints, and anti–citrullinated protein antibodies (ACPAs) form against citrullinated antigens...

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Autori principali: Shelef, Miriam A., Sokolove, Jeremy, Lahey, Lauren J., Wagner, Catriona A., Sackmann, Eric K., Warner, Thomas F., Wang, Yanming, Beebe, David J., Robinson, William H., Huttenlocher, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148484/
https://ncbi.nlm.nih.gov/pubmed/24497204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38393
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