Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis

BACKGROUND: Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and associate with severe disease, we sought to examin...

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Udgivet i:Arthritis Res Ther
Main Authors: Demoruelle, M. Kristen, Wang, Hong, Davis, Ryan L., Visser, Ashley, Hoang, Johnny, Norris, Jill M., Holers, V. Michael, Deane, Kevin D., Darrah, Erika
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182933/
https://ncbi.nlm.nih.gov/pubmed/34092252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02528-5
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