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Smad3 deficient mice have reduced esophageal fibrosis and angiogenesis in a mouse model of egg induced eosinophilic esophagitis

OBJECTIVES: Eosinophilic esophagitis (EoE) is a food triggered disease associated with esophageal fibrosis and stricture formation in a subset of patients. In this study we utilized a murine model of egg (OVA) induced EoE to determine whether inhibiting TGF-β1 signaling through the Smad3 pathway wou...

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Bibliografski detalji
Glavni autori: Cho, JaeYoun, Doshi, Ashmi, Rosenthal, Peter, Beppu, Andrew, Miller, Marina, Aceves, Seema, Broide, David
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148477/
https://ncbi.nlm.nih.gov/pubmed/24590208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPG.0000000000000343
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