Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation

The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus this pathway m...

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Hauptverfasser: Asnaghi, Laura, Lin, Michael H., Lim, Kah Suan, Lim, Kah Jing, Tripathy, Arushi, Wendeborn, Murilo, Merbs, Shannath L., Handa, James T., Sodhi, Akrit, Bar, Eli E., Eberhart, Charles G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148307/
https://ncbi.nlm.nih.gov/pubmed/25166211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105372
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