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FUS is sequestered in nuclear aggregates in ALS patient fibroblasts
Mutations in the RNA-binding protein FUS have been shown to cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigate whether mutant FUS protein in ALS patient–derived fibroblasts affects normal FUS functions in the nucleus. We investigated fibroblasts from two ALS pati...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Cell Biology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148247/ https://ncbi.nlm.nih.gov/pubmed/25009283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-1007 |
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