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Central P2Y(12) receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

In this study the role of P2Y(12) receptors (P2Y(12)R) was explored in rodent models of inflammatory and neuropathic pain and in acute thermal nociception. In correlation with their activity to block the recombinant human P2Y(12)R, the majority of P2Y(12)R antagonists alleviated mechanical hyperalge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Horváth, Gergely, Gölöncsér, Flóra, Csölle, Cecilia, Király, Kornél, Andó, Rómeó D., Baranyi, Mária, Koványi, Bence, Máté, Zoltán, Hoffmann, Kristina, Algaier, Irina, Baqi, Younis, Müller, Christa E., Von Kügelgen, Ivar, Sperlágh, Beáta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148180/
https://ncbi.nlm.nih.gov/pubmed/24971933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.06.011
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