Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma

Diffuse large B cell lymphoma is generally treated by chemotherapy and there is an unmet medical need for novel targeted therapies or combination therapies. Using in vitro screening, we have identified the combination of ibrutinib, an inhibitor of the tyrosine kinase BTK, and AZD2014, an mTOR cataly...

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Autors principals: Ezell, Scott A., Mayo, Michele, Bihani, Teeru, Tepsuporn, Suprawee, Wang, Suping, Passino, Melissa, Grosskurth, Shaun E., Collins, Mike, Parmentier, Julie, Reimer, Corinne, Byth, Kate F.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148116/
https://ncbi.nlm.nih.gov/pubmed/24970801
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