Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma

Diffuse large B cell lymphoma is generally treated by chemotherapy and there is an unmet medical need for novel targeted therapies or combination therapies. Using in vitro screening, we have identified the combination of ibrutinib, an inhibitor of the tyrosine kinase BTK, and AZD2014, an mTOR cataly...

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Detalhes bibliográficos
Main Authors: Ezell, Scott A., Mayo, Michele, Bihani, Teeru, Tepsuporn, Suprawee, Wang, Suping, Passino, Melissa, Grosskurth, Shaun E., Collins, Mike, Parmentier, Julie, Reimer, Corinne, Byth, Kate F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148116/
https://ncbi.nlm.nih.gov/pubmed/24970801
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