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RFX1–dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells
Obatoclax is a small molecule which targets the Bcl-2 family, and is to treat leukemia, lymphoma and lung carcinoma. Previously, an obatoclax analogue, SC-2001, was found to disrupt the protein-protein interactions of the Bcl-2 family and also repress Bcl-XL and Mcl-1 expression via STAT3 inactivati...
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Hoofdauteurs: | , , , , , , , , , |
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Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
Impact Journals LLC
2014
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Onderwerpen: | |
Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148109/ https://ncbi.nlm.nih.gov/pubmed/24952874 |
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