Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity to imatinib therapy....

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書誌詳細
主要な著者: Iurlo, Alessandra, Gianelli, Umberto, Beghini, Alessandro, Spinelli, Orietta, Orofino, Nicola, Lazzaroni, Francesca, Cambiaghi, Stefano, Intermesoli, Tamara, Rambaldi, Alessandro, Cortelezzi, Agostino
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2014
主題:
Clinical Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148089/
https://ncbi.nlm.nih.gov/pubmed/25015329
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