Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity to imatinib therapy....

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Dades bibliogràfiques
Autors principals: Iurlo, Alessandra, Gianelli, Umberto, Beghini, Alessandro, Spinelli, Orietta, Orofino, Nicola, Lazzaroni, Francesca, Cambiaghi, Stefano, Intermesoli, Tamara, Rambaldi, Alessandro, Cortelezzi, Agostino
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Clinical Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148089/
https://ncbi.nlm.nih.gov/pubmed/25015329
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