LY294002 Inhibits Glucocorticoid Induced COX-2 Gene Expression in Cardiomyocytes through a Phosphatidylinositol 3 Kinase Independent Mechanism

Glucocorticoids induce COX-2 expression in rat cardiomyocytes. While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT) induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression. Expression of a...

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Main Authors: Sun, Haipeng, Xu, Beibei, Sheveleva, Elena, Chen, Qin M.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148022/
https://ncbi.nlm.nih.gov/pubmed/18657281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2008.05.024
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