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Corticosteroids Induce Cyclooxygenase 1 Expression in Cardiomyocytes: Role of Glucocorticoid Receptor and Sp3 Transcription Factor

Cyclooxygenase (COX) encodes a rate-limiting enzyme in the biosynthesis of prostanoids. Although COX-1 is constitutively expressed in many tissues, we found that glucocorticoids cause elevated expression of COX-1 gene in cardiomyocytes. Corticosterone (CT) at physiologically relevant doses (0.05–1 μ...

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Detalles Bibliográficos
Main Authors: Sun, Haipeng, Sheveleva, Elena, Chen, Qin M.
Formato: Artigo
Idioma:Inglês
Publicado: The Endocrine Society 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631370/
https://ncbi.nlm.nih.gov/pubmed/18599619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0302
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