OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action

Motivation: Several computational methods have been developed to identify cancer drivers genes—genes responsible for cancer development upon specific alterations. These alterations can cause the loss of function (LoF) of the gene product, for instance, in tumor suppressors, or increase or change its...

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Bibliographic Details
Main Authors: Schroeder, Michael P., Rubio-Perez, Carlota, Tamborero, David, Gonzalez-Perez, Abel, Lopez-Bigas, Nuria
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Eccb 2014 Proceedings Papers Committee
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147920/
https://ncbi.nlm.nih.gov/pubmed/25161246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu467
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