Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy

Motivation: Non–small-cell lung cancer (NSCLC) is the leading cause of cancer death in the United States. Targeted tyrosine kinase inhibitors (TKIs) directed against the epidermal growth factor receptor (EGFR) have been widely and successfully used in treating NSCLC patients with activating EGFR mut...

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Detalhes bibliográficos
Main Authors: Kim, Jihye, Vasu, Vihas T., Mishra, Rangnath, Singleton, Katherine R., Yoo, Minjae, Leach, Sonia M., Farias-Hesson, Eveline, Mason, Robert J., Kang, Jaewoo, Ramamoorthy, Preveen, Kern, Jeffrey A., Heasley, Lynn E., Finigan, James H., Tan, Aik Choon
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Discovery Note
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147888/
https://ncbi.nlm.nih.gov/pubmed/24812339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu323
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