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Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates
BACE1, a membrane-bound aspartyl protease that is implicated in Alzheimer’s disease, is the first protease to cut the amyloid precursor protein resulting in the generation of amyloid-β and its aggregation to form senile plaques, a hallmark feature of the disease. Few other native BACE1 substrates ha...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Libertas Academica
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4147752/ https://ncbi.nlm.nih.gov/pubmed/25288897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BECB.S8383 |
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