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Deficits in Neuronal Cytochrome P450 Activity Attenuate Opioid Analgesia but not Opioid Side Effects
Morphine-like analgesics act on μ opioid receptors in the CNS to produce highly effective pain relief, but the same class of receptors also mediates non-therapeutic side effects. The analgesic properties of morphine were recently shown to require the activity of a brain neuronal cytochrome P450 epox...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4147671/ https://ncbi.nlm.nih.gov/pubmed/25062792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.07.028 |
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