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Metformin directly acts on mitochondria to alter cellular bioenergetics

BACKGROUND: Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin remains poorly understood. METHODS: We performed respirometry and stable isotope...

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Autors principals: Andrzejewski, Sylvia, Gravel, Simon-Pierre, Pollak, Michael, St-Pierre, Julie
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147388/
https://ncbi.nlm.nih.gov/pubmed/25184038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-2-12
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