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Metformin directly acts on mitochondria to alter cellular bioenergetics

BACKGROUND: Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin remains poorly understood. METHODS: We performed respirometry and stable isotope...

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Detalhes bibliográficos
Main Authors: Andrzejewski, Sylvia, Gravel, Simon-Pierre, Pollak, Michael, St-Pierre, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147388/
https://ncbi.nlm.nih.gov/pubmed/25184038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-2-12
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