Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzym...

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Main Authors: Ritorto, Maria Stella, Ewan, Richard, Perez-Oliva, Ana B., Knebel, Axel, Buhrlage, Sara J., Wightman, Melanie, Kelly, Sharon M., Wood, Nicola T., Virdee, Satpal, Gray, Nathanael S., Morrice, Nicholas A., Alessi, Dario R., Trost, Matthias
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147353/
https://ncbi.nlm.nih.gov/pubmed/25159004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5763
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