Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzym...

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Bibliografische gegevens
Hoofdauteurs: Ritorto, Maria Stella, Ewan, Richard, Perez-Oliva, Ana B., Knebel, Axel, Buhrlage, Sara J., Wightman, Melanie, Kelly, Sharon M., Wood, Nicola T., Virdee, Satpal, Gray, Nathanael S., Morrice, Nicholas A., Alessi, Dario R., Trost, Matthias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147353/
https://ncbi.nlm.nih.gov/pubmed/25159004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5763
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