Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzym...

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Détails bibliographiques
Auteurs principaux: Ritorto, Maria Stella, Ewan, Richard, Perez-Oliva, Ana B., Knebel, Axel, Buhrlage, Sara J., Wightman, Melanie, Kelly, Sharon M., Wood, Nicola T., Virdee, Satpal, Gray, Nathanael S., Morrice, Nicholas A., Alessi, Dario R., Trost, Matthias
Format: Artigo
Langue:Inglês
Publié: Nature Pub. Group 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147353/
https://ncbi.nlm.nih.gov/pubmed/25159004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5763
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