Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: Implications for genetic testing

AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct...

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Detalles Bibliográficos
Main Authors: Papp, Janos, Kovacs, Marietta E, Olah, Edith
Formato: Artigo
Idioma:Inglês
Publicado: Baishideng Publishing Group Co., Limited 2007
Assuntos:
Rapid Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147123/
https://ncbi.nlm.nih.gov/pubmed/17569143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v13.i19.2727
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