TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for degradation, plays a broad role in health and disease states. Here we screened the TRIM family for roles in autophagy and found that half of TRIMs modulated autophagy. In mechanistic studies we show that TRIMs ass...

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Detalhes bibliográficos
Main Authors: Mandell, Michael A., Jain, Ashish, Arko-Mensah, John, Chauhan, Santosh, Kimura, Tomonori, Dinkins, Christina, Silvestri, Guido, Münch, Jan, Kirchhoff, Frank, Simonsen, Anne, Wei, Yongjie, Levine, Beth, Johansen, Terje, Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146662/
https://ncbi.nlm.nih.gov/pubmed/25127057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.06.013
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