A Critical Role for the mTORC2 Pathway in Lung Fibrosis

A characteristic of dysregulated wound healing in IPF is fibroblastic-mediated damage to lung epithelial cells within fibroblastic foci. In these foci, TGF-β and other growth factors activate fibroblasts that secrete growth factors and matrix regulatory proteins, which activate a fibrotic cascade. O...

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Bibliografiske detaljer
Main Authors: Chang, Wenteh, Wei, Ke, Ho, Lawrence, Berry, Gerald J., Jacobs, Susan S., Chang, Cheryl H., Rosen, Glenn D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146613/
https://ncbi.nlm.nih.gov/pubmed/25162417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106155
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